Confidence in Processor Array Outputs Under Periodic Application of Concurrant Error Detection

Coordinated Science Laboratory was formerly known as Control Systems LaboratorySDIO/IST and Office of Naval Research / N00014-89-K-0070National Aeronautics and Space Administration (NASA) / NAG 1-613Department of the Navy and Office of the Chief of Naval Research / N00014-91-J-128

Performance Evaluation of Redundant Disk Array Support for Transaction Recovery

Coordinated Science Laboratory was formerly known as Control Systems LaboratoryNational Aeronautics and Space Administration / NAG 1-613Department of the Navy / N00014-91-J-128

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study

Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

La santé, moteur des transitions agricole, alimentaire et environnementale: Réflexion prospective pluridisciplinaire Nexus Santé : entre Agriculture -Alimentation - Environnement Rapport de synthèse

La notion de Nexus est récemment apparue dans un certain nombre d’instances internationales dans le prolongement des publications du Millenium mettant en avant 17 objectifs pour un développement durable au niveau mondial. Utilisée à l’occasion, par exemple, des réflexions sur les relations entre énergie-eau-alimentation, ou entre climat-services écosystémiques-santé ), la notion de Nexus a été proposée pour tenir compte du fait que parmi les 17 objectifs mis en avant, certains sont étroitement liés, de façon positive ou négative, et doivent donc être associés dans la construction des priorités de recherche et la définition ou l’évaluation des politiques publiques.Les réflexions sur le Nexus Santé-Environnement-Agriculture-Alimentation s’inscrivent dans cette perspective en incitant à (i) tenir ensemble dans l’analyse ces différentes composantes de façon prendre en compte la complexité des interactions entre les dimensions économiques, sociales, environnementales et sanitaires des activités qui se déroulent au sein du système alimentaire, (ii) exploiter les synergies possibles entre objectifs ou domaines d’action généralement considérés séparément.Cette nécessité d’une « reconnexion » entre les enjeux de santé, alimentation, agriculture et environnement, étayée par les impacts environnementaux, sociaux, sanitaires des modèles agricoles et alimentaires en place a émergé au croisement de différents courants de la littérature